Lantrida (Donislecel-Jujn) for Type 1 Diabetes

Overview
Lantrida is a treatment approved by the U.S. Food and Drug Administration (FDA) for adults with type 1 diabetes who experience repeated episodes of severe hypoglycemia (dangerously low blood sugar) despite intensive diabetes management and education. It is used for those who cannot achieve target HbA1c levels (a measure of blood sugar control) through traditional diabetes treatments. Lantrida is also known by its drug name, donislecel-jujn.

Lantrida is a cellular therapy that involves the infusion of allogeneic pancreatic islet cells (cells from a donor pancreas) into the liver. These cells are thought to help regulate blood sugar by producing insulin, the hormone that controls blood glucose levels.

How do I take it?
Prescribing information states that Lantrid is administered through an infusion into the hepatic portal vein (the vein that carries blood to the liver). The therapy is delivered as a cellular suspension. The infusion must be completed within six hours of product release. The drug should be administered exactly as prescribed by a health care provider.

Side effects
Common side effects of Lantrid include infections (bacterial, viral, or fungal), which may be severe due to the required immunosuppression (medications that lower the immune system’s activity). Other side effects include liver laceration (tearing) or hematoma (bruising), hemorrhage (bleeding), intra-abdominal bleeding, and elevated portal pressure (increased blood pressure in the portal vein).

Rare but serious side effects may include malignancy (cancer), severe anemia (low red blood cell count), portal vein thrombosis (blood clots in the portal vein), and graft rejection (the body’s immune system attacking the transplanted cells). There is also a risk of transmitting donor-derived infections, and product administration may elevate panel reactive antibodies (PRA), potentially affecting a person’s eligibility for future organ transplants, such as a kidney transplant.

For more information about this treatment, visit:

Label: Lantidra — Donislecel Solution — DailyMed

Lantrida — Drugs.com